• A germ cell mutation that would inactivate passage of proteins and nucleoproteins into and out of the nucleus would result in:
• A. Slow development and neurological defects.
• B. No effect, since transport could occur spontaneously.
• C. Death of the zygote.
• D. Failure to form a neural tube.
• E. No implantation of the blastocyst into the uterine wall.
 
• What is the major change in small GTPase proteins caused by hydrolysis of the bound GTP to GDP?
• A. A loss of one negative charge
• B. A change in shape
• C. Loss of stability
• D. Movement from the membrane to the cytosol
• E. Loss of the ability to bind nucleotide exchange factors
 
• Wherein lays the specificity in the transport of proteins into and out of the nucleus?
• A. The ability to bind Ran-GTP
• B. The ability of the chaperone to bind to the pore complex
• C. The ability to bind to a chaperone such as α,β-importin
• D. Possesion of a peptide sequence or signal patch that can bind chaperones
• E. Possesion of a shape and size less than 10 nm in diameter
 
• What are the four major events required for transport from the cytoplasm to the nucleus?
 
• What are the four major events required for transport from the nucleus to the cytoplasm?
 
• How do transmembrane proteins move from the cytoplasm to the nucleus (hint: look at the first figure in the tutorial)?