Alterations in Oxygenation --Hematology/Coagulation

Reading:

Porth, C.M. (2007)  Essentials of Pathophysiology:  Selected portions of chapters 10-11 and pages 179-180. 

Purposes:

Describe the process by which hematopoiesis occurs in the bone marrow;

Identify the functions of the cellular components of the blood;

Describe the consequences of deficiencies and excess of each type of hematopoietic cell;

Discuss the clinical features and pathologic alterations of disorders of red blood cells and platelets.

Reading Guide:

Again, as in the last module, to help you determine which parts of the chapters are to be emphasized, refer to the written syllabus for guidance on included topics. 

Also, review the textbook website at http://thePoint.LWW.com/PorthEssentials for links to chapter-related resources with animations and chapter review questions.

Terminology:

The list below contains terminology and concepts you should know:

Study questions:

1. What are some common causes of anemias?
2. What are clinical manifestations of anemia, both acute and chronic?
3. What are normal serum levels that reflect normal erythrocyte and platelet function?
4. Why do individuals with aplastic anemia have problems with bleeding, infection, and dizziness?
5. Which inherited hemolytic anemia is seen in childhood?
6. Why are some coagulation factors present in the bloodstream in inactive form until activated by an enzyme?  Give several examples.
7. How does the body maintain adequate numbers of RBCs in the bloodstream?
8. What are some compensatory mechanisms that the body uses to compensate in conditions of mild anemias?
9. What deficiency leads to pernicious anemia and how is the condition treated?
10. Compare hemostasis and coagulation.
11. What is the main substance of a blood clot?
12. What is the importance of the fibrinolytic system?
13. What effects do thrombocytopenia and thrombocytosis have on the coagulation process?
14. What deficiencies leads to iron deficiency anemia and folate deficiency anemia (OK, OK, who is buried in Grant's tomb?)
15. Which enzyme catalyzes the conversion of fibrinogen to fibrin?

Exercise:

Complete the exercise for Module 4 to see how you're doing on learning the basic physiology of this module. You will also get extra credit for completing this exercise! Remember, you will go to Angel at https://elearning.kumc.edu/angel/frames.aspx to complete the exercise. For more of a challenge, if you think the statement is false, make a mental note of what would need to be changed to correct the wrong information and to make the statement a true one.

Discussion group: 

The deadline for participation in the discussion group for this module is midnight, Sunday, Oct. 22nd.

Remember: This material should be completed by Sept. 29 and will be on the exam scheduled for Oct. 26, 2006, 3-5 p.m. in Room 1050 SON.