Practice Drug Titrations

Ms. Pibb was admitted to ICU with renal failure and has developed multiorgan system dysfunction. Her dry weight was 60 kg. She is receiving the following medications:

Nitroglycerine 50 mg/250 ml D5W at 20 mcg/min

Dopamine 800 mg/250 ml D5W at 8 mcg/kg/min


  1. What rate (ml/hr) do you expect the Nitroglycerine to be infusing?
  2. What rate (ml/hr) do you expect the Dopamine to be infusing?
  3. The physician orders Amrinone loading dose of 0.75 mg/kg to be given over 3 minutes. What dose of Amrinone will Ms. Pibb receive?
  4. After the loading dose you start the Amrinone at 5 mcg/kg/min.  If you have 250 mg/50 ml NS, what rate (ml/hr) will you start the Amrinone infusion?
  5. The physician orders the Dopamine to be decreased to a renal dose of 2 mcg/kg/min. What rate (ml/hr) will you infuse the Dopamine?
  6. The Amrinone is increased to 5 ml/hr. You know the maximum dose of Amrinone is 10 mcg/kg/min. What is the maximum rate (ml/hr) you can infuse the Amrinone?
  7. Two hours later, you need to notify the physician of the Ms. Pibb's condition.  The Amrinone is now infusing at 17 ml/hr. What dose will you tell the physician she is receiving?
  8. Ms. Pibb begins complaining of chest pain. You increase the Nitroglycerine to 15 ml/hr. What dose (mcg/min) is she now receiving?

Answers:    Problem 1 / Problem 2 / Problem 3 / Problem   4 / Problem  5 / Problem   6 / Problem  7 / Problem 8


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Sharon Kumm, University of Kansas School of Nursing, March 2002